Cyber physical systems (CPS) are built of physical components that are integrated into the cyber (virtual) world of computing. Such systems offer many open questions and challenges, such as time modelling, big data mining, system awareness, coordinating activities and managing collaboration within and with external systems. Many of the published work focusses on how virtual and physical systems can be designed, coordinated and managed. We argue that drawing a borderline between virtual and physical is misleading the design of CPS especially for the integration of humans. In this paper, we present a holistic modelling approach to enhance classical CPS towards human-centered CPS. The approach is based on our generic coordination model. The goal is not to create human-like systems, but rather a holistic integration of enactive entities (e.g. humans, animals, plants, cells) into CPS. Closely connected to this integration is also the understanding and modelling of cognitive coordination. We argue that this approach could enable CPS to integrate human intelligence and to become a smart partner for daily human activities.