In this paper we present a new CPS model that considers humans as holistic beings, where mind and body operate as a whole and characteristics like creativity and empathy emerge. These characteristics influence the way humans interact and collaborate with technical systems. Our vision is to integrate humans as holistic beings within CPS in order to move towards a human-machine symbiosis. This paper outlines a model for human-centered cyber-physical systems (HCPSs) that is based on our holistic system model URANOS. The model integrates human skills and values to make them accessible to the technical system, similarly to the way they are accessible to humans in human-to-human interaction. The goal is to reinforce the human being in his feeling of being in control of his life experience in a world of smart technologies. It could also help to reduce human bio-costs like stress, job fears, etc. The proposed model is illustrated by the case study of smart industrial machines, dedicated machines for smart factories, where we test the human integration through conversation.